AI Article Synopsis
- Osteocytes are crucial for maintaining bone health and are the primary target for parathormone, which helps regulate calcium levels.
- They produce sclerostin, which inhibits the activity of osteoblasts (cells that build bone), and RANKL, a key player in the formation of osteoclasts (cells that break down bone).
- When osteocytes experience stress or damage, they undergo apoptosis (programmed cell death), which signals other healthy osteocytes to stimulate osteoclasts to resorb and repair bone.
Article Abstract
New data concerning the function of osteocytes as the central regulators of bone homeostasis are briefly outlined. It is established that osteocytes are the main target cells for parathormone. They are a rich source of sclerostin, the main inhibitor of osteoblast activity, and of the RANKL cytokine, the most important regulator of osteoclastogenesis. Under shear stress causing microinjury, osteocytes enter programmed cell death (apoptosis) and osteocyte apoptosis is a signal for nearby healthy osteocytes to activate osteoclasts to resorb bone.
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| http://dx.doi.org/10.5604/15093492.1193009 | DOI Listing |
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