Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s40596-016-0499-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing Data Science and Genomics Capacity of a Historically Black Medical College Through Interdisciplinary Training and Research Collaborations.
J Biotechnol Biomed
October 2024
Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN, USA.
As data grows exponentially across diverse fields, effectively leveraging big data has become increasingly crucial. In data science and computational genomics, however, minority groups, including African Americans, are significantly underrepresented, coupled with the lack of resources and infrastructure in minority-serving institutions. This paper summarizes the second phase of our funded project that aims to enhance the data science capacity of Meharry Medical College (MMC), a Historically Black College/University (HBCU), by providing training and fostering collaborations between data scientists and researchers in basic science and biomedical fields.
View Article and Find Full Text PDFReported outcomes following cytoreductive surgery for colorectal peritoneal metastases: A systematic review to inform evidence-based practice and international consensus.
Colorectal Dis
January 2025
Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Aim: Cytoreductive surgery provides a chance for long-term survival and cure in selected patients with colorectal peritoneal metastases. As clinical and academic interest in this field increases, heterogeneity in outcome reporting hinders the valid and meaningful synthesis of data into high-quality meta-analyses. The aim of this systemic review was to investigate variability in outcome reporting following cytoreductive surgery with or without intraperitoneal chemotherapy for colorectal peritoneal metastases.
View Article and Find Full Text PDFSingle-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta.
Placenta
December 2024
Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel. Electronic address:
Introduction: Single-cell RNA-seq (scRNA-seq) revolutionized our understanding of tissue complexity in health and disease and revealed massive transcriptional dysregulation across placental cell classes in early-onset, but not late-onset preeclampsia (PE). However, the multinucleated syncytium is largely inaccessible to cell dissociation. Nuclei isolation and single-nuclei RNA-seq may be preferable in the placenta; not least considering compatibility with long-term tissue storage.
View Article and Find Full Text PDFEvaluating ChatGPT's Multilingual Performance in Clinical Nutrition Advice Using Synthetic Medical Text: Insights from Central Asia.
J Nutr
December 2024
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan. Electronic address:
Background: While large language models like ChatGPT-4 have demonstrated competency in English, their performance for minority groups speaking underrepresented languages, as well as their ability to adapt to specific socio-cultural nuances and regional cuisines, such as those in Central Asia (e.g., Kazakhstan), still requires further investigation.
View Article and Find Full Text PDFPOP-REFINE: A Comprehensive Framework for Evaluating and Optimizing Representativeness in Clinical Trials.
Clin Pharmacol Ther
December 2024
Flatiron Health, New York, NY, USA.
Clinical research has historically failed to include representative levels of historically underrepresented populations and these inequities continue to persist. Ensuring representativeness in clinical trials is crucial for patients to receive clinically appropriate treatment and have equitable access to novel therapies; enhancing the generalizability of study results; and reducing the need for post-marketing commitments focused on underrepresented groups. As demonstrated by recent legislation and guidance documents, regulatory agencies have shown an increased interest in understanding how novel therapies will impact the patient population that will receive them.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!