AI Article Synopsis
- Researchers have used 3D printing to create tissue-like materials made of tiny aqueous compartments separated by lipid bilayers.
- A light-activated DNA promoter allows for the expression of specific genes in synthetic cells, enabling control over protein production.
- This process leads to the development of a functional model for neuronal transmission, facilitating controlled electrical communication between different groups of cells.
Article Abstract
We have previously used three-dimensional (3D) printing to prepare tissue-like materials in which picoliter aqueous compartments are separated by lipid bilayers. These printed droplets are elaborated into synthetic cells by using a tightly regulated in vitro transcription/translation system. A light-activated DNA promoter has been developed that can be used to turn on the expression of any gene within the synthetic cells. We used light activation to express protein pores in 3D-printed patterns within synthetic tissues. The pores are incorporated into specific bilayer interfaces and thereby mediate rapid, directional electrical communication between subsets of cells. Accordingly, we have developed a functional mimic of neuronal transmission that can be controlled in a precise way.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820383 | PMC |
| http://dx.doi.org/10.1126/sciadv.1600056 | DOI Listing |
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