Objective: Proton magnetic resonance spectroscopy (H-MRS) measurement of liver metabolism in intrauterine growth restriction rats has seldom been reported. This study investigated the application of H-MRS in assessing liver metabolism in newborn pups that experienced intrauterine growth restriction.
Methods: Intra-uterine growth restriction was established by feeding rats low-protein diets during pregnancy. Newborn pups received conventional magnetic resonance imaging and H-MRS using a 3.0T whole body MR scanner at 3, 8 and 12 weeks post birth.
Results: The success rate of H-MRS was 83.33%. Significantly lower body weight, BMI and body length at 3 weeks as well as significantly lower body weight, BMI and waist circumference at 8 and 12 weeks were observed in newborn pups of IUGR rats compared with pups of control rats. Significant differences in ACho/HO, ACr/HO, AGlx/HO and ALipid/HO at 3 and 8 weeks as well as significant differences in ACr/HO, ALipid/HO and AGlx/HO at 12 weeks were observed between pups of control rats and pups of IUGR rats.
Conclusion: H-MRS allows noninvasive assessment of liver metabolism in the rat and demonstrated the poor liver development of rats that experienced IUGR.
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| http://dx.doi.org/10.1080/14767058.2016.1174989 | DOI Listing |
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