AI Article Synopsis
- Researchers developed bispecific antibodies through advanced computational protein design techniques and negative state data.
- They used a strategy combining these methods with carefully chosen mutations to enhance their results.
- The engineered antibodies were able to form heterodimers with a high purity rate, reaching up to 93%.
Article Abstract
In this issue of Structure, Leaver-Fay et al. (2016) engineer bispecific antibodies using multistate computational protein design with negative state repertoires. In combination with additional mutations selected rationally, they produced antibodies that assembled as heterodimers with up to 93% purity.
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| http://dx.doi.org/10.1016/j.str.2016.03.012 | DOI Listing |
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