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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility.
Biomolecules
January 2025
Research and Education Resource Center, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. Little is known about how altered palmitoylation affects function at the systemic level and contributes to CNS pathology. However, recent studies suggested a role for the downregulation of palmitoyl acetyltransferase (DHHC) 21 gene expression in the development of Major Depressive Disorder (MDD)-like syndrome.
View Article and Find Full Text PDFEvidence for Bxy-npr-21 on controlling juveniles' growth and modulating male sexual arousal: from molecules to behaviors.
Pest Manag Sci
January 2025
College of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou, 311300, China.
Background: Bursaphelenchus xylophilus is considered a quarantine plant nematode species, that causes major damage to pine ecosystems globally. However, there are few reports on the identification and function of the sex pheromone receptors involved in mating. The function of Bxy-npr-21 as a potential sex pheromone receptor gene was verified from molecules to behaviors in this study.
View Article and Find Full Text PDFChallenges and barriers for the adoption of personalized medicine in Europe: the case of Oncotype DX Breast Recurrence Score test.
Diagnosis (Berl)
December 2024
Sarah Cannon Research Institute, Nashville, TN, USA.
Article Synopsis
- Personalized medicine in oncology has great potential, but its adoption in Europe is hindered by various challenges, as seen with the Oncotype DX Breast Recurrence Score assay.
- The case study details obstacles faced in integrating this genomic test into European healthcare from 2004 to 2018, including issues with clinical evidence, reimbursement, and regulatory processes.
- Key findings from the TAILORx study suggest that, for certain breast cancer patients, endocrine therapy may suffice without the need for additional adjuvant chemotherapy, highlighting the importance of personalized treatment approaches.
Pathogen class-specific transcriptional responses derived from PBMCs accurately discriminate between fungal, bacterial, and viral infections.
PLoS One
December 2024
Division of Infectious Diseases, Duke University, Durham, North Carolina, United States of America.
Article Synopsis
- Immune responses to acute infections share common elements across different pathogens, which can aid in creating better diagnostics and treatments.
- Analysis of gene expression in white blood cells shows these common patterns, helping to identify the type of infection (viral or bacterial).
- A study identified a 41-gene signature that classifies infections with high accuracy and a smaller 21-gene subset that distinguishes between specific infections, underscoring the potential for developing effective diagnostic tools.
Synergistic anticancer effects of interleukin-21 combined with therapeutic peptides in multiple cancer cells.
Biotechnol Lett
November 2024
Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Background: Interleukin-21 (IL-21) is a cytokine produced by various cell types, including T cells, natural killer cells, myeloid cells, and B cells, and has a broad range of potential applications in cancer therapy. To improve the therapeutic index, we explored the use of fusion technologies that involved linking other anticancer peptides to the IL-21 gene using specific linkers.
Objectives: This study aimed to compare the anticancer potential of IL-21 and IL-21 fusion proteins.
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