Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019202 | PMC |
| http://dx.doi.org/10.1126/scisignal.aaf6029 | DOI Listing |
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