Orthogonal strategy for the synthesis of dual-functionalised β(3)-peptide based hydrogels.

We have described a new class of hydrogelator based on helical β(3)-peptides carrying a bioactive payload. The β(3)-peptides self-assemble in aqueous solution to form a nanofibrous mesh resulting in a stable hydrogel. The simple design provides the versatility for attaching different functional payloads to the β(3)-peptide scaffold to develop new materials.