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Biosensing made easy with PEG-targeted bi-specific antibodies. | LitMetric

Biosensing made easy with PEG-targeted bi-specific antibodies.

Chem Commun (Camb)

Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD 4072, Australia and Centre for Personalised NanoMedicine, AIBN, University of Queensland, Brisbane, QLD 4072, Australia and School of Chemistry and Molecular Biosciences (SCMB), University of Queensland, Brisbane, QLD 4072, Australia.

Published: April 2016

AI Article Synopsis

Article Abstract

Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs)--which exhibit binding capability for two separate targets--offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c6cc01916aDOI Listing

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