Obesity and kidney disease: Beyond the hyperfiltration.

Int J Immunopathol Pharmacol

Division of Hypertension and Nephrology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.

Published: September 2016

AI Article Synopsis

  • Overweight and obesity contribute to around 13.8% of kidney disease in men and 24.9% in women in industrialized countries.
  • Obesity-related kidney damage, known as glomerulopathy, is becoming increasingly recognized as a serious health issue.
  • The paper will explore how fat tissue, especially visceral fat, plays a crucial role in causing chronic kidney damage linked to obesity, independent of conditions like hypertension and diabetes.

Article Abstract

In industrialized countries, overweight and obesity account for approximately 13.8% and 24.9% of the kidney disease observed in men and women, respectively. Moreover, obesity-associated glomerulopathy is now considered as "an emerging epidemic." Kidney function can be negatively impacted by obesity through several mechanisms, either direct or indirect. While it is well established that obesity represents the leading risk factor for type 2 diabetes and hypertension, awareness that obesity is associated with direct kidney damage independently of hypertension and diabetes is still not widespread. In this paper we will discuss the emerging role of adipose tissue, particularly in the visceral depot, in obesity-induced chronic kidney damage.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806769PMC
http://dx.doi.org/10.1177/0394632016643550DOI Listing

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