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Synthesis of the C22-C40 Domain of the Azaspiracids. | LitMetric

Synthesis of the C22-C40 Domain of the Azaspiracids.

Org Lett

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.

Published: April 2016

An efficient synthesis of the C22-C40 domain of the azaspiracids is described. The synthetic route features a Nozaki-Hiyama-Kishi (NHK) coupling and chelation controlled Mukaiyama aldol reaction to access an acyclic intermediate and a double-intramolecular-hetero-Michael addition (DIHMA) to provide the FG-ring system bridged ketal.

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Source
http://dx.doi.org/10.1021/acs.orglett.6b00557DOI Listing

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