AI Article Synopsis
- Chromosomal translocations can create fusion proteins that lead to tumor development, but their effects on non-coding RNAs, especially circular RNAs (circRNAs), have not been thoroughly studied.
- This research reveals that certain cancer-related chromosomal translocations result in the formation of fusion circRNAs (f-circRNAs), which are produced from gene segments affected by those translocations.
- F-circRNAs enhance cell transformation, increase cell survival and treatment resistance, and promote tumor growth in live models, providing new insights into the molecular mechanisms of cancer and potential advancements for diagnosis and therapy.
Article Abstract
Chromosomal translocations encode oncogenic fusion proteins that have been proven to be causally involved in tumorigenesis. Our understanding of whether such genomic alterations also affect non-coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored. Here, we show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs (f-circRNA) that are produced from transcribed exons of distinct genes affected by the translocations. F-circRNAs contribute to cellular transformation, promote cell viability and resistance upon therapy, and have tumor-promoting properties in in vivo models. Our work expands the current knowledge regarding molecular mechanisms involved in cancer onset and progression, with potential diagnostic and therapeutic implications.
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| http://dx.doi.org/10.1016/j.cell.2016.03.020 | DOI Listing |
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