AI Article Synopsis
- The study explored cognitive deficits in patients with frontal lobe epilepsy (FLE) to improve preoperative assessments for epilepsy surgery.
- It involved testing 34 FLE patients, 37 with medial temporal lobe epilepsy (MTLE), and 22 healthy individuals across various cognitive functions, revealing similar performance between FLE and MTLE except for mental flexibility.
- The findings indicate overlapping cognitive issues between FLE and MTLE, suggesting a need for personalized neuropsychological evaluations and EEG monitoring to differentiate between the two types of epilepsy in a clinical setting.
Article Abstract
Background: This study investigated whether certain cognitive deficits are associated with frontal lobe epilepsy (FLE) aiming to contribute with localization data to the preoperative assessment of epilepsy surgery candidates.
Methods: We evaluated 34 patients with refractory FLE, 37 patients with refractory medial temporal lobe epilepsy (MTLE), and 22 healthy individuals in attention, psychomotor speed, motor function, verbal memory span, verbal fluency, response inhibition/interference, concept formation and set shifting, anticipation and planning, global memory.
Results: Neuropsychological performances of FLE and MTLE were similar, with the only exception the WCST-number of categories index, measuring mental flexibility, in which MTLE patients performed significantly worse than FLE patients. Left-FLE patients presented more perseverative responding compared to both other patient groups and healthy controls (HCs), while left-MTLE patients showed worse sorting abilities than the other epilepsy groups.
Conclusions: Our findings suggest a weak cognitive differentiation between FLE and MTLE, probably attributed to the intricate nature of fronto-temporal connectivity frequently resulting in overlapping deficits as well as the confounding effects of seizure-related variables. In clinical practice, a highly individualized (idiographic) neuropsychological approach along with the inclusion of concurrent EEG recordings (e.g., interictal coupling) may be of help for neuropsychologists in identifying FLE patients from those with medial temporal pathology presenting frontal dysfunction as a secondary cognitive symptom.
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| http://dx.doi.org/10.1007/s00701-016-2786-4 | DOI Listing |
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