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Lentivirus-mediated gene therapy for Fabry disease: 5-year End-of-Study results from the Canadian FACTs trial.
Clin Transl Med
January 2025
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Background: Fabry disease is an X-linked lysosomal storage disorder due to a deficiency of α-galactosidase A (α-gal A) activity. Our goal was to correct the enzyme deficiency in Fabry patients by transferring the cDNA for α-gal A into their CD34+ hematopoietic stem/progenitor cells (HSPCs). Overexpression of α-gal A leads to secretion of the hydrolase; which can be taken up and used by uncorrected bystander cells.
View Article and Find Full Text PDFCan a Situational Judgment Test Identify Trainees at Risk of Professionalism Issues? A Multi-Institutional, Prospective Cohort Study.
Acad Med
October 2022
J.Q. Young is professor and chair, Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, and senior vice president, behavioral health, Northwell Health, Lake Success, New York; ORCID: https://orcid.org/0000-0003-2219-5657 .
Purpose: To determine whether overall situational judgment test (SJT) scores are associated with programs' clinical competency committee (CCC) ratings of trainee professionalism, any concerning behavior, and concerning behavior requiring active remediation at 2 time periods.
Method: In fall 2019, trainees from 17 U.S.
Predicting Performance of First-Year Residents: Correlations Between Structured Interview, Licensure Exam, and Competency Scores in a Multi-Institutional Study.
Acad Med
March 2019
B. Marcus-Blank was a graduate student, Industrial/Organizational Psychology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota, at the time of the study. The author is now senior analyst, Talent Assessment and Coaching, General Mills, Minneapolis, Minnesota. J.A. Dahlke is a graduate student, Industrial/Organizational Psychology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota. J.P. Braman is associate professor, Department of Orthopaedic Surgery, University of Minnesota Medical School, Minneapolis, Minnesota. E. Borman-Shoap is assistant professor and vice chair for education, Department of Pediatrics, and program director, Pediatrics Residency Program, University of Minnesota Medical School, Minneapolis, Minnesota. E. Tiryaki is associate professor, Department of Neurology, University of Minnesota Medical School, and associate chief of staff for education, Minneapolis Veterans Affairs (VA) Health Care System, Minneapolis, Minnesota. J. Chipman is professor and vice chair for education, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota. J.S. Andrews is vice president, GME Innovations, American Medical Association, Chicago, Illinois. P.R. Sackett is professor of psychology, Industrial/Organizational Psychology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota. M.J. Cullen is director of evaluation for graduate medical education, University of Minnesota Medical School, Minneapolis, Minnesota.
Purpose: To determine whether scores on structured interview (SI) questions designed to measure noncognitive competencies in physicians (1) predict subsequent first-year resident performance on Accreditation Council for Graduate Medical Education (ACGME) milestones and (2) add incremental validity over United States Medical Licensing Examination (USMLE) Step 1 and Step 2 Clinical Knowledge scores in predicting performance.
Method: The authors developed 18 behavioral description questions to measure key noncognitive competencies (e.g.
My personal experiences at the BEST Medical Center: A day in the clinic-the morning.
Clin Dermatol
May 2017
Division of Hematology and Oncology, Clinical Science, and Center for Personalized Cancer Therapy and Clinical Trials Office, University of California San Diego Moores Cancer Center, San Diego, California.
Dr. Ida Lystic is a gastroenterologist who trained at the OTHER (Owen T. Henry and Eugene Rutherford) Medical Center, after having completed her MD degree at the prestigious Harvey Medical School (recently renamed the Harvey Provider School).
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