Axinellamines A and B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836294 | PMC |
| http://dx.doi.org/10.1002/anie.201600007 | DOI Listing |
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