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Unacylated Ghrelin Protects Against Age-Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle.
Aging Cell
December 2024
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sarcopenia, the progressive loss of muscle mass and function, universally affects older adults and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to healthspan, no pharmacological therapies are currently available. Ghrelin is a gut-released hormone that increases appetite and body weight through acylation.
View Article and Find Full Text PDFChanges in body composition, adipokines, ghrelin, and FGF23 in growth hormone-deficient children during rhGH therapy.
Endokrynol Pol
August 2024
Endocrinology Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania.
Introduction: Beyond growth acceleration, growth hormone (GH) therapy improves body composition of GH-deficient (GHD) children due to the interaction of GH with lipid and carbohydrate metabolism, possibly mediated by adipokines secreted by adipose tissue and ghrelin. To promote linear growth, it is essential to have normal phosphate homeostasis. Fibroblast growth factor 23 (FGF23) is a known regulator of serum phosphorus and may be responsible for the increased renal phosphorus reabsorption observed during GH therapy.
View Article and Find Full Text PDFRegulation of peripheral tissue substrate metabolism by the gut-derived hormone ghrelin.
Metabol Open
March 2024
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Ghrelin increases in the circulation prior to entrained mealtimes, with the acylated (AG) form functioning to stimulate food intake and growth hormone release. Acutely, AG induces whole-body insulin resistance, potentially to maintain glycemia between meals. Alternatively, chronic administration of both AG and the unacylated isoform of ghrelin (unAG) is associated with improved skeletal muscle insulin sensitivity as well as reduced intramuscular lipids and inflammation.
View Article and Find Full Text PDFEffects of ghrelin on food caching behaviour and body composition in black-capped chickadees (Poecile atricapillus).
Gen Comp Endocrinol
May 2024
Departments of Psychology and Advanced Facility for Avian Research, University of Western Ontario, Canada; Departments of Biology Advanced Facility for Avian Research, University of Western Ontario, Canada. Electronic address:
Several metabolic hormones signal an organism's energy balance to the brain and modulate feeding behaviours accordingly. These metabolic signals may also regulate other behaviour related to energy balance, such as food caching or hoarding. Ghrelin is one such hormone, but it appears to exert different effects on appetite and fat levels in birds and mammals.
View Article and Find Full Text PDFLongitudinal Changes in Acylated versus Unacylated Ghrelin Levels May Be Involved in the Underlying Mechanisms of the Switch in Nutritional Phases in Prader-Willi Syndrome.
Horm Res Paediatr
August 2024
Dutch Reference Center for Prader-Willi Syndrome, Rotterdam, The Netherlands.
Introduction: Prader-Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. An elevated, more unfavorable ratio between acylated and unacylated ghrelin (AG/UAG ratio) might play a role in the underlying mechanisms of this switch. We aimed to assess the evolution of the appetite-regulating hormones acylated ghrelin (AG) and unacylated ghrelin (UAG) and the AG/UAG ratio and their association with the change in eating behavior in children with PWS, compared to healthy age-matched controls.
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