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Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer.
Auris Nasus Larynx
April 2022
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Black thyroid is characterized by a rare pigment change observed almost exclusively in patients taking minocycline. We present the case of a 72-year-old man diagnosed with T3N3bM0 stage IVB hypopharyngeal squamous cell carcinoma who had been taking minocycline for approximately 18 months as a treatment for prurigo chronica multiformis. Initial treatment consisted of total pharyngolaryngoesophagectomy, bilateral neck dissection, total thyroidectomy, pharyngeal reconstruction using a free jejunal autograft, and creation of a permanent tracheostoma.
View Article and Find Full Text PDFMinocycline-induced Cartilage Hyperpigmentation Mimicking Alkaptonuria in a Patient with Knee Pain.
J Rheumatol
April 2016
Professor of Medicine, Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA.
Blue-Black Trachea as a Result of Minocycline-induced Hyperpigmentation.
Am J Respir Crit Care Med
February 2016
2 Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Tokyo, Japan.
Minocycline is a semisynthetic broad-spectrum tetracycline used for its bacteriostatic and anti-inflammatory properties in the treatment of moderate to severe acne vulgaris. Minocycline-induced hyperpigmentation (MIH) is a well-recognized phenomenon documented to involve a wide array of anatomic locations including the skin and nails, the sclera and conjunctiva, the oral cavity, and the skeleton and cartilage, as well as within viscera and body fluids. Oral involvement typically includes the hard tissues (eg, alveolar bone, roots, crowns of teeth).
View Article and Find Full Text PDFMinocycline-induced periarticular black bones in inflamed joints which underwent arthroplastic reconstruction.
Clin Orthop Surg
September 2012
Department of Orthopedic Surgery, Yamagata University School of Medicine, Yamagata, Japan.
Background: Minocycline-induced pigmentation of bone (black bone) is well described in tooth-bearing intra-oral bone, but is less known in periarticular bone in patients who have undergone total joint arthroplasty. On a retrospective basis, we investigated the short-term clinico-radiological results of total joint arthroplasties in which the patient developed minocycline-induced periarticular black bone.
Methods: We found 5 cases (0.
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