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Safety and efficacy of transbronchial cryobiopsy for elderly lung cancer patients.
BMC Pulm Med
December 2024
Department of Respiratory Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 470-1192, Aichi, Japan.
Background: The increasing prevalence of lung cancer in the elderly population necessitates a closer evaluation of diagnostic and therapeutic approaches. This study aimed to compare the safety and diagnostic efficacy of transbronchial lung cryobiopsy (TBLC) between patients ≥ 80 years and younger patients.
Methods: A retrospective review was conducted of 96 patients diagnosed with peripheral lung cancer who underwent TBLC between April 2021 and October 2023.
Ultrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence.
BMJ Open Respir Res
December 2024
Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
Background: Limited data exist on the reliability, efficacy and safety of ultrasound-guided transbronchial cryobiopsy for suspicious mediastinal and hilar lesions. This study shares findings from implementing this method and compares the results with those of the standard endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).
Methods: Patients undergoing diagnostic bronchoscopy for mediastinal or hilar lesions in four Swiss centres were included.
Endoscopic ultrasound with bronchoscope-guided transesophageal cryobiopsy: A case series with technical insights, key enablers, and review of literature.
Respirol Case Rep
December 2024
Division of Respiratory Medicine, Department of Medicine Sarawak General Hospital, Jalan Hospital Kuching Malaysia.
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established technique for lung cancer staging and the diagnosis of mediastinal diseases. Recently, the paradigm of EBUS guided mediastinal sampling with conventional cytology has shifted over to histology specimens through the use of cryobiopsy. This case series explores the novel technique, key enablers, and potential advantages of endoscopic ultrasound with bronchoscope-guided transesophageal cryobiopsy (EUS-B-TEC).
View Article and Find Full Text PDFElevated PD-L1 and PECAM-1 as Diagnostic Biomarkers of Acute Rejection in Lung Transplantation.
Transpl Int
December 2024
Department of Immunology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Article Synopsis
- - Acute cellular rejection (ACR) is common after lung transplants and can lead to chronic lung problems and affect survival rates; diagnosing it can be tricky due to inconsistent interpretations among pathologists.
- - This study explored the use of immunohistochemistry to identify specific markers (like PD-L1 and PECAM-1) in lung tissue samples from lung transplant patients to improve ACR diagnosis.
- - Results showed that PD-L1 levels were higher in patients with ACR, indicating an immune response suppression effort, and there were notable differences in PECAM-1 levels, highlighting these markers’ potential usefulness for detecting ACR.
Unlabelled: Purpose of the study We investigated the incidence of chronic pulmonary complications in allogeneic hematopoietic cell transplantation (allo-HCT) recipients and analyzed the role of transbronchial cryobiopsy (cryoTBB) as a tool to determine the nature of pulmonary changes and to guide clinical decisions.
Methods: Patients who survived at least 6 months post HCT were included in the study. Pulmonary functional tests (PFTs) were performed in all patients as a screening tool.
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