AI Article Synopsis
- A study examined the link between perioperative β-blockade (use of beta-blockers) and the recurrence/metastasis of breast cancer in over 1,000 surgical patients.
- Research found that stage II patients using β-blockers had a lower risk of cancer recurrence, with a significant hazard ratio indicating a protective effect.
- The study also revealed that triple-negative brain-metastatic breast cancer cells have heightened β2-adrenergic receptors which, when activated, lead to increased cell growth and movement, effects that were countered by β-blockers like propranolol, suggesting they may help prevent metastasis.
Article Abstract
In response to recent studies, we investigated an association between perioperative β-blockade and breast cancer metastases. First, a retrospective study examining perioperative β-blocker use and cancer recurrence and metastases was conducted on 1,029 patients who underwent breast cancer surgery at the City of Hope Cancer Center between 2000 and 2010. We followed the clinical study and examined proliferation, migration, and invasion in vitro of primary and brain-metastatic breast cancer cells in response to β2-activation and inhibition. We also investigated in vivo the metastatic potential of propranolol-treated metastatic cells. For stage II breast cancer patients, perioperative β-blockade was associated with decreased cancer recurrence using Cox regression analysis (hazard's ratio =0.51; 95% CI: 0.23-0.97; p=0.041). Triple-negative (TN) brain-metastatic cells were found to have increased β2-adrenergic receptor mRNA and protein expression relative to TN primary cells. In response to β2-adrenergic receptor activation, TN brain-metastatic cells also exhibited increased cell proliferation and migration relative to the control. These effects were abrogated by propranolol. Propranolol decreased β2-adrenergic receptor-activated invasion. In vivo, propranolol treatment of TN brain-metastatic cells decreased establishment of brain metastases. Our results suggest that stress and corresponding β2-activation may promote the establishment of brain metastases of TN breast cancer cells. In addition, our data suggest a benefit to perioperative β-blockade during surgery-induced stress with respect to breast cancer recurrence and metastases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869944 | PMC |
| http://dx.doi.org/10.3892/or.2016.4710 | DOI Listing |
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