Potassium-binding resins are widely used in the treatment of hyperkalemia, mostly in the acute setting. Gastrointestinal adverse events, although reported, are not frequently seen due to its short course of use. This report describes a case involving an end-stage renal disease patient on hemodialysis who developed a colonic mass after being on sodium polystyrene sulfonate chronically for persistent hyperkalemia. Gastrointestinal symptoms developed late during the treatment rather than early as reported previously in the literature. This mass was mistaken for a carcinomatous lesion, which initiated an extensive work-up as well as hospitalization that nearly resulted in a subtotal colectomy.
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http://dx.doi.org/10.1155/2016/3692086 | DOI Listing |
Case Rep Gastrointest Med
February 2022
Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA.
. Sodium polystyrene sulfonate is a resin used to treat hyperkalemia. Colonic mucosal injury, intestinal ischemia, necrosis, and perforation have been widely reported in the literature, but few cases have reported upper gastrointestinal injury and identify the endoscopic features.
View Article and Find Full Text PDFTurk Patoloji Derg
February 2020
Department of Histopathology, Mubarak Al Kabir Hospital, JABRIYA, KUWAIT.
< strong > Objective: < /strong > Medication resins such as Kayexalate and Sevelamer used in the setting of chronic kidney disease for the correction of hyperkalemia and hyperphosphatemia are associated with gastrointestinal mucosal injury. In this study we describe the clinico-pathological features of Resin-induced gastrointestinal mucosal injury highlighting the histo-morphological appearances and differential diagnoses. The aim of this study is to increase the awareness of pathologists and clinicians alike to an under-reported etiology and pattern of intestinal mucosal injury related to medical resin therapy which may at times pose a clinical emergency.
View Article and Find Full Text PDFCase Rep Nephrol
April 2016
Department of Medicine/Cardiology Division, Woodhull Medical Center, Brooklyn, NY 11206, USA; Medicine Department, NYU School of Medicine, New York, NY 10016, USA.
Potassium-binding resins are widely used in the treatment of hyperkalemia, mostly in the acute setting. Gastrointestinal adverse events, although reported, are not frequently seen due to its short course of use. This report describes a case involving an end-stage renal disease patient on hemodialysis who developed a colonic mass after being on sodium polystyrene sulfonate chronically for persistent hyperkalemia.
View Article and Find Full Text PDF1. The Na, K and water content of stools, and of gut contents removed from the terminal ileum, caecum and colon were determined in normal and Na-depleted rats and the p.d.
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