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A case report of a rare etiology of an abdominal cystic lesion in adults: Peritoneal inclusion cysts.
Int J Surg Case Rep
January 2025
Department of Visceral and Digestive Surgery, Monastir University Hospital, Monastir, Tunisia.
Introduction And Importance: Peritoneal inclusion cysts (PICs), also known as peritoneal mesothelial cysts, are rare, benign cystic lesions primarily occurring in the abdominopelvic cavity of premenopausal women with histories of pelvic surgery or inflammation. These cysts can present with nonspecific symptoms and may mimic other abdominal pathologies, making diagnosis challenging.
Case Presentation: A 41-year-old male with no significant medical history, who experienced progressive nonspecific abdominal pain over several months.
The Role of CD56, HBME-1, and CK19 Immunohistochemical Markers in the differential Diagnosing of Thyroid Neoplasms.
Niger Med J
November 2024
Windsor University School of Medicine, Brightons Estate, Cayon, St. Kitts.
Article Synopsis
- The study investigates the role of Immunohistochemistry (IHC) markers (CD56, HBME-1, CK19) in diagnosing malignant thyroid neoplasms, highlighting the challenges of distinguishing between benign and malignant lesions using traditional histopathology.
- Out of 60 thyroid specimens analyzed, 68.33% were found malignant, with significant loss of CD56 expression in malignant cases and high specificity for CK19 in differentiating follicular neoplasms.
- The research underscores the importance of incorporating IHC markers to improve diagnostic accuracy for thyroid cancers, particularly in cases of follicular variant papillary thyroid carcinoma and follicular thyroid carcinoma.
SOX17 Expression in Mesotheliomas and Benign Mesothelial Proliferations: Implications for Differential Diagnosis With Gynecologic Carcinomas.
Int J Gynecol Pathol
October 2024
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
SOX17 has recently emerged as a novel immunohistochemical marker for cancers of endometrial and ovarian origin with improved specificity compared with the widely used Mullerian marker PAX8. However, evaluation of SOX17 in benign and malignant peritoneal mesothelial proliferations remains limited, and these may mimic gynecologic carcinomas, particularly on small biopsies. We evaluated SOX17 and PAX8 expression in 20 benign mesothelial lesions (5 adenomatoid tumors, 5 well-differentiated papillary mesothelial tumors, and 10 peritoneal inclusion cysts) and 16 epithelioid peritoneal mesotheliomas.
View Article and Find Full Text PDFThe Diagnostic Accuracy of Claudin-4 Immunochemistry in Differentiating Metastatic Carcinomas From Mesothelial Processes in Serous Effusion Cytology: A Systematic Review and Meta-analysis.
Arch Pathol Lab Med
June 2024
From School of Medicine, European University Cyprus, Nicosia, Cyprus (Kleinaki, Ishak, Arnaouti, Nikas).
Context.—: Distinguishing metastatic carcinomas from mesotheliomas or reactive mesothelial cells in pleural, peritoneal, and pericardial effusions is a common diagnostic problem cytopathologists encounter.
Objective.
Large and Extensive Multilocular Peritoneal Inclusion Cysts Lack Genomic Alterations and Follow an Indolent Clinical Course Despite Rare Recurrences.
Am J Surg Pathol
September 2024
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Peritoneal inclusion cysts (PICs) are unilocular or multilocular cystic lesions lined by bland mesothelial cells. While most are small and localized, rare examples may be large or multifocal with diffuse peritoneal involvement, causing clinical and even pathologic concern for malignancy. We examined 20 PIC, including 8 large solitary and 12 multifocal lesions.
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