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Alzheimers Dement
December 2024
University of Kentucky College of Medicine, Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: We currently lack in the dementia field accurate, noninvasive, quick, and affordable screening tools for brain dysfunctions associated with early subtle risk of mild cognitive impairment (MCI). Our Kentucky aging cohort demonstrates that asymptomatic older individuals with MCI-like frontal memory-related brainwave patterns convert to MCI within a short 5-year period, as opposed to individuals with NC-like patterns (1) that remain normal 10 years later (2). Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease (3).
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Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Stronger default mode (DMN) and bilateral frontoparietal control network (FPCN) resting-state functional connectivity are associated with reduced β-amyloid (Aβ)-related cognitive decline in cognitively unimpaired older adults, who were predominantly Aβ negative. This suggests that these networks might support cognitive resilience in the face of early AD pathology but it remains unclear whether these effects are apparent in preclinical AD. We investigated whether left-FPCN, right-FPCN, and DMN connectivity moderated the effect of Aβ on cognitive decline using a large multi-site dataset from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) study.
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Alzheimers Dement
December 2024
Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Background: South Asian (SA) older adults are one of the fastest growing US populations developing Alzheimer's disease (AD) and related dementias (ADRD). Compared to non-Hispanic white (NHW) Americans, SA are hesitant to enroll in neuropsychological and MRI research. This status complicates accurate assessment and diagnosis.
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Alzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
Background: Locus coeruleus (LC) imaging using neuromelanin-sensitive (NM) MRI sequences is a promising biomarker for detecting early Alzheimer's Disease (AD). Although automatic approaches have been developed to estimate LC integrity by measuring its intensity, these techniques most often rely on a single template built in a standardized space and/or depend on a number of voxels to be accounted that is defined a priori. Thus, these algorithms make it impossible to perform direct volumetric analyses and do not properly account for inter-individual anatomical variability.
View Article and Find Full Text PDFBackground: Neuroinflammatory processes, assessed by cytokines such as interleukins, are implicated in vascular disease and amyloid-β (Aβ) burden. White matter hyperintensities (WMH), markers of small vessel cerebrovascular disease, are associated with memory impairment and Alzheimer's disease (AD)-related cortical atrophy. Here, we used structural equation modeling (SEM) to test whether inflammatory markers are related to markers of AD pathology and neurodegeneration through their impact on WMH.
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