Context: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD).
Objectives: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury.
Material And Methods: Human L-FABP chromosomal transgenic (T) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R.
Results: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase.
Discussion And Conclusion: These markers could detect higher risk of progression to CKD.
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| http://dx.doi.org/10.3109/1354750X.2016.1153723 | DOI Listing |
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