Objectives: The accuracy of computer-aided design/computer- aided manufacturing (CAD/CAM) systems is linked to their technical characteristics and reliability for manufacturing the restoration designed. The aim of this study was to compare the accuracy of fit of zirconia copings manufactured with different CAD/CAM systems and their capacity to conform to pre-established spacer design settings.
Methods: Sixty zirconia copings were manufactured by three CAD/CAM systems, with their spacers set as recommended by their manufacturer on occlusal, axial, and marginal surfaces. The 3D triple-scan optical technique was used to obtain a fit mapping and to analyze the marginal and axial accuracy of fit. The reliability of the 3D measurement method was estimated using intraclass correlation and repeatability coefficients. The preparation coping interface width results were statistically analyzed using non-parametric analysis (Kruskal-Wallis, one-way ANOVA, and Wilcoxon signedrank tests) (P < 0.05).
Results: The repeatability coefficient was 6, 8, and 15 μm for axial, marginal, and occlusal interface width measurements, respectively. For the three systems tested, no differences were found in the marginal area of the copings studied, with a mean fitting accuracy ranging from 54.3 to 66.6 μm interface width. Statistically significant differences between groups were observed for the fitting accuracy measured in axial and occlusal areas. With the spacers set in the different areas, mean fit measurements of the zirconia copings were significantly larger, with an increased fit width ranging from 30 to 73 μm.
Significance: The three CAD/CAM systems evaluated allowed similar marginal accuracy but failed to reproduce the pre-established spacer parameters, with larger spacing showing throughout.
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J Craniomaxillofac Surg
January 2025
Department of Oral and Maxillo-Facial Surgery, Head and Neck Institute, University Hospital Center of Nice, 31 avenue de Valombrose, 06100, Nice, France; Nice Côte d'Azur Clinical Research Unit (UR2CA), France. Electronic address:
There has been a recent increase in the global demand for jawline augmentation. Managing angle definition in patients undergoing orthognathic surgery remains challenging owing to the characteristics of classic mandibular osteotomy, which mostly allows sagittal mandibular movements but cannot modify the ramus height. The advent of computer-assisted surgical planning and computer-aided design/computer-aided manufacturing techniques for patient-specific implant fabrication has introduced new methods for jawline management.
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Department of Oral and Maxillofacial Surgery, Kunming Medical University School and Hospital of Stomatology, Kunming, China.
Background/purpose: The functional and aesthetic reconstruction of the mandible can be achieved by using the double-barrel vascularized free fibula flap. The purpose of this study was to use multiple integrated techniques to more effectively reconstruct the mandible, some contains of our unique ideas.
Materials And Methods: 21 patients were included in this study.
Sci Rep
January 2025
Center for Advanced Laser Technologies (CETAL), National Institute for Lasers, Plasma and Radiation Physics, Magurele-Ilfov, 077125, Romania.
Nature offers unique examples that help humans produce artificial systems which mimic specific functions of living organisms and provide solutions to complex technical problems of the modern world. For example, the development of 3D micro-nanostructures that mimic nocturnal insect eyes (optimized for night vision), emerges as promising technology for detection in IR spectral region. Here, we report a proof of principle concerning the design and laser 3D printing of all ultrastructural details of nocturnal moth Grapholita Funebrana eyes, for potential use as microlens arrays for IR detection systems.
View Article and Find Full Text PDFRSC Adv
January 2025
LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa Caparica Portugal
Despite significant strides in improving cancer survival rates, the global cancer burden remains substantial, with an anticipated rise in new cases. Immune checkpoints, key regulators of immune responses, play a crucial role in cancer evasion mechanisms. The discovery of immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 has revolutionized cancer treatment, with monoclonal antibodies (mAbs) becoming widely prescribed.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Management and Engineering, University of Padova, Stradella San Nicola 3, 36100, Vicenza, Italy. Electronic address:
Digital workflows have revolutionized dentistry, especially when it comes to fabrication of complete dentures through Computer-Aided Design and Computer-Aided Manufacturing (CAD-CAM) procedures. Digital articulators manage to simulate mandibular movements and are emerging as alternatives to mechanical articulators like the Gerber semi-adjustable model. Despite being a promising tool, digital articulators require refinement in order to grant consistent functionality and effective occlusal balance.
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