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Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures.
Neurol Neuroimmunol Neuroinflamm
November 2021
From the Department of Neurology (A.N.B., T.M., J.E.H., C.S.N., C.N.C., A.M.B., P.S.S., R.J.C., R.M., M.A.N.), University of Colorado School of Medicine, Aurora; Department of Medical Laboratory Sciences (M.M., S.E.F.), University of Vermont, Burlington; Department of Ophthalmology (P.S.S., M.A.N.), University of Colorado School of Medicine, Aurora; Department of Neurosurgery (P.S.S.), University of Colorado School of Medicine, Aurora; and Department of Immunology and Microbiology (R.J.C.), University of Colorado School of Medicine, Aurora.
Background And Objectives: Varicella zoster virus (VZV) antigen has been detected in temporal arteries (TAs) of individuals with giant cell arteritis (GCA), the most common systemic vasculitis in older adults. Thus, we explored the contribution of VZV to GCA pathogenesis.
Methods: Formalin-fixed, paraffin-embedded TA sections from biopsy-positive GCA participants with VZV antigen (GCA/VZV-positive; n = 20) and without (GCA/VZV-negative, n = 20) and from normal participants with VZV antigen (control/VZV-positive, n = 11) and without (control/VZV-negative, n = 20) were analyzed by targeted RNA sequencing of the whole human transcriptome (BioSpyder TempO-Seq).
Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis.
Rheumatology (Oxford)
August 2020
Northern Clinical School, University of Sydney, St Leonards, Sydney, New South Wales, Australia.
Objectives: There is uncertainty if varicella zoster virus (VZV) triggers GCA. This is based on discordant reports of VZV detection in GCA temporal artery biopsies. We conducted a multimodal evaluation for VZV in the inception Giant Cell Arteritis and PET Scan (GAPS) cohort.
View Article and Find Full Text PDFVZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100+ temporal arteries.
Neurol Neuroimmunol Neuroinflamm
April 2016
University of Colorado School of Medicine (D.G., T.W., N.K., M.A.N.), Aurora; and East Carolina University (P.J.B.), Greenville, NC.
Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis.
JAMA Neurol
November 2015
Department of Neurology, University of Colorado School of Medicine, Aurora20Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora.
Article Synopsis
- Giant cell arteritis (GCA) is the most common type of systemic vasculitis in older adults, diagnosed through temporal artery biopsy, which often yields negative results despite the condition's progression in some patients.
- A study analyzed varicella-zoster virus (VZV) infection in temporal arteries (TAs) from patients suspected of having GCA but with negative biopsy results, as well as normal TAs from age-matched individuals.
- The findings showed a significantly higher presence of VZV antigen in GCA-negative (64%) and GCA-positive (73%) TAs compared to normal TAs (22%), suggesting a potential link between VZV infection and GCA pathology.
Varicella zoster virus infection associated with erythema multiforme in children.
Infection
August 2001
Dept. of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva.
Background: Erythema multiforme (EM) is a vesiculobullous disorder with variable manifestations which predominantly affects the skin. It is regarded as a hypersensitivity disorder which is triggered by multiple factors such as infection, drugs and food. Varicella zoster virus (VZV) has rarely been reported as an etiological agent, despite its high incidence as a pathogen in childhood.
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