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One case of Actinotignum schaalii-induced repeated infections at periumbilical scar accompanied by abscess formation and literature review.
BMC Infect Dis
December 2024
Department of Infectious Diseases, the Third People's Hospital of Chengdu, Chengdu, Sichuan, 610031, China.
To enhance the current clinical understanding and improve the diagnosis and treatment of Actinotignum schaalii infections, we have presented here a report of the case of recurrent infections at a periumbilical scar, induced by Actinotignum schaalii and complicated by abscess formation in a 50-year-old woman with persistent festering at the site of a periumbilical scar after laparoscopy 9 years ago, with subsequent ruptures over the past 2 years. Physical examination revealed a radial fold scar with localized redness and slight swelling of the skin below the navel. Although no significant increase in the local skin temperature was noted, tenderness was present.
View Article and Find Full Text PDFFabrication and characterization of potato short amylose, zein, and pectin ternary composite particles stabilized pickering emulsions and their application on nuciferine delivery.
Food Res Int
December 2024
Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:
Article Synopsis
- Nuciferine has potential health benefits like lowering blood sugar and fat but faces challenges due to poor water solubility and low bioavailability.
- Researchers created a ternary composite using short amylose, zein, and pectin to stabilize Pickering emulsions that can effectively deliver nuciferine, significantly improving its stability and bioavailability.
- The optimal conditions for preparing these emulsions, which achieved a high encapsulation rate for nuciferine, resulted in small particle sizes and demonstrated good stability against various environmental factors, supporting better delivery and effectiveness of the active ingredient.
Axial muscle-fibre orientations in larval zebrafish.
J Anat
November 2024
Experimental Zoology Group, Wageningen University, Wageningen, The Netherlands.
Most teleost fish propel themselves with lateral body waves powered by their axial muscles. These muscles also power suction feeding through rapid expansion of the mouth cavity. They consist of muscle segments (myomeres), separated by connective tissue sheets (myosepts).
View Article and Find Full Text PDFThe Design of Novel 3D-Printed, Moulded, and Oral Viscous Budesonide Formulations for Paediatrics: A Comparative Evaluation of Their Mucoadhesive Properties.
Pharmaceutics
October 2024
Departamento de Ingeniería Química y Tecnología Farmacéutica, Campus de Anchieta, Universidad de La Laguna, 38200 La Laguna, Spain.
Background/objectives: Paediatric eosinophilic oesophagitis (EoE) treatment is challenging due to the limited number of age-appropriate formulations. This study aims to develop and evaluate oral viscous suspensions and solid formulations of budesonide (BUD), focusing on their in vitro mucoadhesive properties, to enhance drug delivery and therapeutic outcomes in paediatric EoE.
Methods: This study encompasses the development of oral viscous suspensions and orodispersible solid formulations (moulded tablets and 3D-printed dosage forms) containing BUD.
Evaluation of bacterial anti-adhesion and sustained antimicrobial abilities of chlorhexidine gluconate-loaded phase-transited lysozyme nanoparticle suspension on dentine: An ex vivo study.
Int Endod J
October 2024
Department of Endodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
Aim: To evaluate the effect of chlorhexidine gluconate-loaded phase-transited lysozyme (CHG@PTL) coating on inhibiting bacterial adhesion and biofilm formation in an ex vivo root canal dentine model.
Methodology: The physicochemical and structural characteristics of CHG@PTL nanoparticle suspension and its coating formed on the dentine surface were analysed by thioflavin T fluorescence assay, transmission electron microscopy and confocal laser scanning microscopy (CLSM). The sustained chlorhexidine release profile of the CHG@PTL coating on the dentine surface was compared with that of the 2% CHG solution.
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