AI Article Synopsis
- The role of mitochondria in cancer cell survival is emphasized, focusing on how they regulate redox states and produce reactive oxygen species (ROS).
- Various adaptations of mitochondria in tumors, including energy metabolism changes and responses to hypoxia, are analyzed.
- Research shows sodium dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, is effective in certain tumors like sarcoma 37, but not in others like Lewis lung carcinoma, highlighting tumor-specific responses.
Article Abstract
The novel ideas of fundamental role of mitochondria in the maintenance of viability of malignant cells have been reviewed. The modern state of research is considered in detail, including: mitochondrial control of the cellular redox state, sites of reactive oxygen species (ROS) production in inner mitochondrial membrane and antioxidant protection systems. Specificities of the structural-functional mitochondrial remodelling in malignant tumors, the mechanisms of the energy metabolism reprogramming, enhancement of the ROS production and adaptation to the hypoxic conditions and metabolic stress are analyzed. The available data including our research on transplanted tumors indicate that cytotoxic action of sodium dichloroacetate (the inhibitor of pyruvate dehydrogenase kinase) depends on biological properties of tumors and intensity of structural-functional mitochondrial rearrangement. Dichloroacetate turned out to be effective for sarcoma 37, but not for Lewis lung carcinoma.
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| http://dx.doi.org/10.15407/ubj87.06.019 | DOI Listing |
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