Background/aim: Calcium acetate/magnesium carbonate (CaMg) is a recent phosphate binder that has been shown to have protective cardiovascular (CV) effects in animal models. The aim of this study was to evaluate the relationship between CaMg therapy and CV risk markers like pulse pressure (PP), left ventricular mass index (LVMI) and valvular calcifications compared to sevelamer or no phosphate binder (NPB) therapy in chronic hemodialysis (HD) patients.
Methods: We performed a 48-month prospective study in 138 HD patients under hemodiafiltration with a dialysate Mg concentration of 0.5 mmol/l. Patients underwent treatment with CaMg or sevelamer for at least 36 months or NPB therapy. Demographic, clinical, biochemical and echocardiographic parameters were evaluated at baseline and after a 48-month period.
Results: At the end of the study, patients who had taken CaMg showed a significant reduction in PP (p < 0.001), LVMI (p = 0.003), aortic (p = 0.004) and mitral valve calcifications (p = 0.03) compared with NPB patients. Patients under CaMg showed a significant reduction of PP (p < 0.001), LVMI (p = 0.01) and aortic valve calcifications (p = 0.02) compared to sevelamer patients. In a multivariable analysis, CaMg therapy was negatively associated with progression of LVMI (p = 0.02) and aortic valve calcifications (p = 0.01). Patients under CaMg showed higher serum Mg levels (0.93 ± 0.14 mmol/l) compared to patients under sevelamer (0.87 ± 0.13) or NPB patients (0.82 ± 0.12; p < 0.001).
Conclusions: In prevalent HD patients, the use of CaMg over 48 months was associated with a reduction of PP and LVMI and with a stabilization of aortic valve calcifications. These protective and promising results of this new phosphate binder need to be confirmed in randomized controlled studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000444421 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Serum calcium-magnesium ratio at admission predicts adverse outcomes in patients with acute coronary syndrome.
PLoS One
November 2024
Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Article Synopsis
- A study investigated the link between the serum calcium-magnesium (Ca/Mg) ratio and clinical outcomes in patients with acute coronary syndrome (ACS), suggesting that lower ratios may indicate worse outcomes.
- The research analyzed data from 1,775 ACS patients who underwent coronary procedures, dividing them into four groups based on their Ca/Mg ratios to compare clinical characteristics and postoperative outcomes.
- Results indicated that a higher Ca/Mg ratio correlates with lower risks of major adverse events and in-hospital mortality, emphasizing the potential protective role of magnesium in cardiovascular health.
Multi-element analysis of metals in human pathological and unchanged thyroid glands - pilot study.
Thyroid Res
May 2024
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 50-422, Wroclaw, Poland.
Disturbances in the homeostasis of the elemental composition of thyroid tissue may have serious metabolic and health consequences. It is believed that the accumulation of some metals or the deficiency of others may even cause lethal tumours. Due to the fact that metallomics most often uses human serum to analyse macro and microelements as well as trace elements, it was decided to use material that is more difficult to obtain, but also adds credibility to the research - thyroid tissue samples biopsy.
View Article and Find Full Text PDFDevelopment of cell-laden photopolymerized constructs with bioactive amorphous calcium magnesium phosphate for bone tissue regeneration via 3D bioprinting.
Int J Biol Macromol
May 2024
Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Department of Mechanical Design Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address:
The synthesis of ideal bioceramics to guide the fate of cells and subsequent bone regeneration within the chemical, biological, and physical microenvironment is a challenging long-term task. This study developed amorphous calcium magnesium phosphate (ACMP) bioceramics via a simple co-precipitation method. The role of Mg in the formation of ACMP is investigated using physicochemical and biological characterization at different Ca/Mg molar ratio of the initial reaction solution.
View Article and Find Full Text PDFAssociation of Plasma Metal Levels with Outcomes of Assisted Reproduction in Polycystic Ovary Syndrome.
Biol Trace Elem Res
November 2024
Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province, Department of Education, Key Laboratory of Hengyang City On Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, 421001, Hunan, China.
The objective of this study is to explore the correlation of metal levels with assisted reproductive technology (ART) outcomes in polycystic ovary syndrome (PCOS) patients. The individuals were recruited who met the research criteria, only tubal factor or male infertility served as the control group (n = 40) and patient group was PCOS patients (n = 35). Individuals (n = 75) were divided into PCOS group (n = 35) and control group (n = 40).
View Article and Find Full Text PDFThe clinical significance of calcium/magnesium ratio in primary hyperparathyroidism: unveiling a clinical association.
Hormones (Athens)
September 2024
Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya, Ankara, Turkey.
Purpose: In previous studies, magnesium (Mg) was found to be lower in cases with more severe primary hyperparathyroidism (PHPT) and higher calcium (Ca) levels. This study evaluated the relationship between serum Mg and serum Ca and phosphorus (P) levels in PHPT and their utility in determining the presence of osteoporosis and nephrolithiasis.
Methods: Patients who were followed up with PHPT between March 2019 and March 2023 were analyzed retrospectively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!