Background: This article presents a patient with iridocorneal endothelial (ICE) syndome.
Case Report: A 35-year-old man presented with unilateral slightly decreased visual acuity. Examination by slit-lamp biomicroscopy of the affected eye revealed alterations to the corneal endothelial layer, which had a silver-grey and hammered appearance. Corectopia with the pupil drawn towards an area with peripheral anterior synechiae could be gonioscopically detected. In vivo confocal microscopy of the cornea revealed alterations of the corneal endothelial layers of the affected eye, namely epithelization of the endothelium with pleomorphic epithelioid cells of irregular size and shape, indistinct borders and hyperreflective nuclei.
Conclusion: In vivo confocal microscopy of the cornea is a sensitive diagnostic method for the rapid and early diagnosis of ICE syndrome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00347-016-0244-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lipid nanoparticle-mediated intracameral mRNA delivery facilitates gene expression and editing in the anterior chamber of the eye.
J Control Release
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR 97201, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Biomedical Engineering, Robertson Life Sciences Building, Oregon Health & Science University, Portland, OR 97201, USA. Electronic address:
Lipid nanoparticles (LNPs) have shown great potential in the field of gene therapy for retinal diseases. To expand on this application, we investigated LNP-mediated mRNA delivery to the anterior chamber of the eye via the intracameral (IC) route of administration. Here, we show that IC injections of LNPs facilitated protein expression and gene editing in the trabecular meshwork (TM).
View Article and Find Full Text PDFClinical characteristics, risk factor analysis and outcomes in 61 eyes with graft rejection after descemet stripping endothelial keratoplasty, with a review of literature.
Int Ophthalmol
November 2024
Department of Biostatistics, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Purpose: To report the demographic profile, clinical characteristics, risk factors and outcomes of graft rejection after DSEK.
Methods: A total of 3073 eyes had DSEK between 2012 and 2019, of which 1710 eyes that had follow up of more than one year. Sixty-one eyes who had graft rejection during this period were studied.
One-year outcomes after intraocular collamer lens implantation in hyperopic astigmatism: a retrospective single-center study.
Med Hypothesis Discov Innov Ophthalmol
October 2024
Department of Ophthalmology, King Faisal University, Al-Ahsa, Saudi Arabia.
Background: Astigmatism is the most prevalent refractive error among children and adults, and it can lead to visual impairment if left uncorrected. The management of compound hyperopic astigmatism is more challenging. This study presents the 12-month outcomes of toric implantable collamer lens (ICL) implantation in eyes with hyperopic astigmatism.
View Article and Find Full Text PDFLong-term surgical outcomes of combined Ahmed glaucoma valve implantation and phacoemulsification with intraocular lens implantation for patients with glaucoma secondary to iridocorneal endothelial syndrome.
BMC Ophthalmol
October 2024
Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Background: To assess the long-term outcomes of patients with glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE) who underwent Ahmed glaucoma valve (AGV) implantation combined with phacoemulsification and intraocular lens (IOL) implantation surgery.
Methods: In this non-comparative retrospective case series study, twelve patients with uncontrolled GS-ICE and cataract underwent Ahmed aqueous shunt combined with phacoemulsification and IOL implantation surgery at Beijing Tongren Eye Center between June 2014 and June 2022. Main medical records included best-corrected visual acuity (BCVA), intraocular pressure (IOP), number of antiglaucoma medications (AGM), corneal status and further surgical interventions.
Clinical Outcomes of Endothelial Keratoplasty With a Recipient's Entire Descemet Stripping for Iridocorneal Endothelial Syndrome.
Am J Ophthalmol
February 2025
From the State Key Laboratory of Ophthalmology (X.D., C.O., J.W., C.X., L.F., M.M., J.P., T.H.), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:
Article Synopsis
- The study aimed to determine if completely removing the recipient's Descemet membrane reduces endothelial cell loss (ECL) after Descemet membrane endothelial keratoplasty (DMEK) for patients with iridocorneal endothelial (ICE) syndrome.
- It was a randomized controlled trial that compared two groups of patients: one receiving full Descemet stripping and the other undergoing a standard technique.
- Results showed that those in the entire stripping group experienced significantly lower ECL rates after 9 months, suggesting this technique could help manage ICE syndrome better, although overall visual acuity and complication rates were similar between the two groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!