Microorganisms are rich repositories of genetic material encoding many activities of potential interest. Recent advances make identifying and exploiting the metabolic treasures of uncultured microbes an easier proposition. Improved expression vectors and metagenomic screening techniques make it easier to identify activities of interest. Synthetic biology and efficient genome editing techniques allow microbial genomes to be modified almost without restriction. Computational approaches based on organism-wide analysis of transcription, protein synthesis and metabolic fluxes make it possible to accurately predict the outcome of the metabolic processes and modifications required for optimization. Together these advances represent a major breakthrough in microbial biotechnology that is expected to yield new generations of tailor-made biocatalysts suitable for multiple biotechnological applications.
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http://dx.doi.org/10.1016/j.mib.2016.03.003 | DOI Listing |
Top Curr Chem (Cham)
March 2025
Guizhou Provincial Key Laboratory of Coal Clean Utilization, School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui, 553004, Guizhou, People's Republic of China.
Endohedral metallofullerenes (EMFs) have garnered significant attention for their distinctive properties and potential integration into cutting-edge photoelectric devices. This review provides a comprehensive overview of recent advancements in EMF synthesis, highlighting the novel "self-driven carbon atom implantation" approach that sheds new light on the underlying mechanisms of EMF formation. The discussion delves into pivotal challenges related to yield optimization and purification processes, addressing current limitations and the imperative need for scalable synthesis and improved stability.
View Article and Find Full Text PDFBMC Cancer
March 2025
Department of Orthopedics, College of Medicine, The First Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, 310003, People's Republic of China.
Ovarian cancer (OC) stands as a formidable adversary among women, remaining a leading cause of cancer-related mortality owing to its aggressive and invasive nature. Investigating prognostic markers intricately linked to OC's molecular pathogenesis represents a critical avenue for enhancing patient outcomes and survival prospects. In this comprehensive study, we embarked on a bioinformatics journey, leveraging the vast repository of single nucleotide polymorphism (SNP) data from OC patients available within the TCGA database.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Health Behavior, School of Public Health, Texas A&M University, 1266 TAMU, College Station, TX, 77843, USA.
Social support systems are often the most important factor in initiating and sustaining recovery from substance use disorders (SUDs). The Phoenix is a non-profit organization whose mission is to create communities and host events that harness the transformational power of social connection to promote SUD recovery. Through online surveys and in-depth interviews, this study assessed factors related to support provision within Phoenix members' social networks.
View Article and Find Full Text PDFNano Lett
March 2025
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Borophene, a semimetallic Dirac material with exceptional mechanical and electronic properties, shows great energy storage potential but requires conductive substrates for stability. A strategy for fabricating flexible and conductive rGO-supported borophene supercapacitor electrodes is proposed, featuring a layered assembly of borophene nanosheets sandwiched between rGO layers. This architecture prevents rGO nanosheet restacking, maintaining interlayer spacing at 5.
View Article and Find Full Text PDFCan J Psychiatry
March 2025
Department of Psychiatry, University of Oxford, Oxford, UK.
ObjectiveWe summarize the key steps to develop and assess an innovative online, evidence-based tool that supports shared decision-making in routine care to personalize antidepressant treatment in adults with depression. This PETRUSHKA tool is part of the PETRUSHKA trial (Personalize antidEpressant Treatment foR Unipolar depreSsion combining individual cHoices, risKs, and big datA).MethodsThe PETRUSHKA tool: (a) is based on prediction models, which use a combination of advanced analytics, i.
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