AI Article Synopsis
- Viruses with positive-sense RNA genomes, like picornaviruses and coronaviruses, manipulate host cell membranes to form structures called replication organelles (ROs) that assist in viral genome amplification.
- ROs are specialized compartments that combine viral proteins and essential host factors, creating a favorable environment for the virus's replication process.
- The paper discusses how picornaviruses utilize membrane contact sites to exchange lipids between ROs and other organelles, highlighting a similar strategy used by other +RNA viruses.
Article Abstract
All viruses that carry a positive-sense RNA genome (+RNA), such as picornaviruses, hepatitis C virus, dengue virus, and SARS- and MERS-coronavirus, confiscate intracellular membranes of the host cell to generate new compartments (i.e., replication organelles) for amplification of their genome. Replication organelles (ROs) are membranous structures that not only harbor viral proteins but also contain a specific array of hijacked host factors that create a unique lipid microenvironment optimal for genome replication. While some lipids may be locally synthesized de novo, other lipids are shuttled towards ROs. In picornavirus-infected cells, lipids are exchanged at membrane contact sites between ROs and other organelles. In this paper, we review recent advances in our understanding of how picornaviruses exploit host membrane contact site machinery to generate ROs, a mechanism that is used by some other +RNA viruses as well.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126954 | PMC |
| http://dx.doi.org/10.1016/j.tim.2016.02.017 | DOI Listing |
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