AI Article Synopsis
- - This study looked at how certain HLA class-I and -II genes affect how well relapsing-remitting multiple sclerosis patients respond to IFN-β treatment.
- - Researchers analyzed 231 MS patients (146 responders and 85 nonresponders) alongside 180 healthy controls, correlating their response to IFN-β with specific HLA alleles and haplotypes.
- - Results showed that certain genetic markers (HLA-DRB1*04 and HLA-A*03-B*44-DRB1*04) are linked to better treatment responses, suggesting that genetic testing could help predict patient outcomes before starting therapy.
Article Abstract
Aims: This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients.
Patients & Methods: In this cohort, 231 relapsing-remitting MS patients who are classified into IFN-β responders (n = 146) and nonresponders (n = 85) and 180 ethnic-matched healthy controls were analyzed. Clinical outcome of IFN-β therapy particularly Expanded Disability Status Scale scores were evaluated in relation to HLA-A, -B and -DRB1 alleles and haplotypes.
Results: Increased frequencies of HLA-DRB1*04 allele and HLA-A*03-B*44-DRB1*04 haplotype, and decreased frequency of HLA-B*15 were associated with better response to IFN-β treatment.
Conclusion: The possibility of genetic screening particularly HLA typing prior to starting IFN-β therapy for MS may permit the identification of likely responders or nonresponders.
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| http://dx.doi.org/10.2217/pgs.16.2 | DOI Listing |
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