AI Article Synopsis
- - This study investigates a new cementless technique using titanium mesh implants (TMIs) for treating osteoporotic vertebral compression fractures (VCFs), aiming to avoid complications linked to traditional cement-based treatments.
- - Twelve Merino sheep were used to model osteoporosis and create standardized VCFs, with outcomes assessed after two months through surgical evaluation and imaging techniques like micro-CT.
- - Results indicated that the TMI method effectively facilitated bony healing without injuries or complications, though adding autologous spongiosa grafting did not enhance healing outcomes, paving the way for clinical application of this technique.
Article Abstract
Introduction: Current treatment strategies for osteoporotic vertebral compression fractures (VCFs) focus on cement-associated solutions. Complications associated with cement application are leakage, embolism, adjacent fractures, and compromise in bony healing. This study comprises a validated VCF model in osteoporotic sheep in order to (1) evaluate a new cementless fracture fixation technique using titanium mesh implants (TMIs) and (2) demonstrate the healing capabilities in osteoporotic VCFs.
Methods: Twelve 5-year-old Merino sheep received ovariectomy, corticosteroid injections, and a calcium/phosphorus/vitamin D-deficient diet for osteoporosis induction. Standardized VCFs (type AO A3.1) were created, reduced, and fixed using intravertebral TMIs. Randomly additional autologous spongiosa grafting (G1) or no augmentation was performed (G2, n = 6 each). Two months postoperatively, macroscopic, micro-CT and biomechanical evaluation assessed bony consolidation.
Results: Fracture reduction succeeded in all cases without intraoperative complications. Bony consolidation was proven for all cases with increased amounts of callus development for G2 (58.3%). Micro-CT revealed cage integration. Neither group showed improved results with biomechanical testing.
Conclusions: Fracture reduction/fixation using TMIs without cement in osteoporotic sheep lumbar VCF resulted in bony fracture healing. Intravertebral application of autologous spongiosa showed no beneficial effects. The technique is now available for clinical use; thus, it offers an opportunity to abandon cement-associated complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785241 | PMC |
| http://dx.doi.org/10.1155/2016/4094161 | DOI Listing |
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