The first nickel catalyzed deprotonative cross coupling between C(sp)-H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
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| http://dx.doi.org/10.1039/c5sc01589h | DOI Listing |
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