AI Article Synopsis
- * Researchers identified and expressed a gene called SurA1 from a specific A. baumannii strain and examined its impact on the bacteria's ability to grow and infect.
- * Results showed that a strain lacking the SurA1 gene had reduced growth rates and virulence, indicating that SurA1 is crucial for the bacteria’s fitness and ability to cause disease.
Article Abstract
Acinetobacter baumannii is a Gram-negative bacillus that causes nosocomial infections, such as bacteremia, pneumonia, and meningitis and urinary tract and wound infections. In the present study, the surface antigen protein 1 (SurA1) gene of A. baumannii strain CCGGD201101 was identified, cloned and expressed, and then its roles in fitness and virulence were investigated. Virulence was observed in the human lung cancer cell lines A549 and HEp-2 at one week after treatment with recombinant SurA1. One isogenic SurA1 knock-out strain, GR0015, which was derived from the A. baumannii strain CCGGD201101 isolated from diseased chicks in a previous study, highlighted the effect of SurA1 on fitness and growth. Its growth rate in LB broth and killing activity in human sera were significantly decreased compared with strain CCGGD201101. In the Galleria mellonella insect model, the isogenic SurA1 knock-out strain exhibited a lower survival rate and decreased dissemination. These results suggest that SurA1 plays an important role in the fitness and virulence of A. baumannii.
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| http://dx.doi.org/10.1016/j.vetmic.2016.02.018 | DOI Listing |
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Analysis of virulence proteins in pathogenic Acinetobacter baumannii to provide early warning of zoonotic risk.
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View Article and Find Full Text PDFCharacterization of a highly virulent and antimicrobial-resistant Acinetobacter baumannii strain isolated from diseased chicks in China.
Microbiol Immunol
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Key Laboratory of Zoonosis Research, Ministry of Education/Institute of Zoonosis/College of Veterinary Medicine, Jilin University, Xi An Da Lu 5333, Changchun 130062, China.
Article Synopsis
- Poultry husbandry is crucial for China's agricultural economy, but chicks frequently face risks from infectious diseases, leading to significant economic losses.
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Characterization of surface antigen protein 1 (SurA1) from Acinetobacter baumannii and its role in virulence and fitness.
Vet Microbiol
April 2016
Key Laboratory of Zoonosis Research, Ministry of Education/Institute of Zoonosis/College of Veterinary Medicine, Jilin University, Xi An Da Lu 5333, Changchun 130062, China. Electronic address:
Article Synopsis
- * Researchers identified and expressed a gene called SurA1 from a specific A. baumannii strain and examined its impact on the bacteria's ability to grow and infect.
- * Results showed that a strain lacking the SurA1 gene had reduced growth rates and virulence, indicating that SurA1 is crucial for the bacteria’s fitness and ability to cause disease.
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