AI Article Synopsis

  • Tc99m-PYP scintigraphy is being used for diagnosing transthyretin cardiac amyloidosis (CA) but its use varies widely across US medical centers.
  • A survey sent to 2785 ASNC members resulted in responses from 101 centers, revealing that only 24% perform the scan specifically for CA diagnosis.
  • The study indicates a need for standardization in the utilization and interpretation of Tc99m-PYP imaging due to low usage rates and significant differences in practices among institutions.

Article Abstract

Background: Tc99m-pyrophosphate (Tc99m-PYP) scintigraphy has emerged as a diagnostic modality for transthyretin (TTR) cardiac amyloidosis (CA). We sought to examine the variability in test utilization across multiple centers in the US.

Methods: An electronic, web-based survey addressing specifics on Tc-99m PYP imaging was emailed to ASNC members, totaling 2785 recipients. Only one response per institution was allowed.

Results: Responses were collected from 101 centers between July 2 and July 27, 2015. Among the respondents, 24% performed Tc-99m PYP specifically for CA diagnosis. The most commonly used dose was 20 mCi (37%) and most centers (35%) imaged 1 hour after injection. Scans were most often interpreted by cardiologists (60%). Quantification of uptake was performed in 57% of institutions with almost half (43%) utilizing the heart-to-contralateral lung (H/CL) ratio.

Conclusions: This national survey shows relatively low penetrance and high variability in Tc99m-PYP scintigraphy for CA diagnosis highlighting the need for standardization.

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http://dx.doi.org/10.1007/s12350-016-0478-3DOI Listing

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