AI Article Synopsis
- The blood-brain barrier presents challenges for treating brain tumors and infections, but the Ommaya reservoir, developed in 1963, provides a solution by allowing access to ventricular spaces.
- The reservoir has diverse applications, including managing cancer pain, treating chronic CNS infections, preventing CNS issues in leukemia, and addressing leptomeningeal cancers.
- The authors discuss the reasoning behind its use, current applications, surgical methods, and possible complications associated with the Ommaya reservoir and similar systems.
Article Abstract
A major obstacle to the effective systemic therapy of intracranial malignancies and infections, the bloodbrain barrier was overcome by the development of the Ommaya reservoir in 1963. Initially used in treating cryptococcal meningitis, this closed system for continued access to the ventricular spaces has a variety of applications. They include treatment of cancer pain, chronic or recurrent CNS infection, prophylaxis of CNS involvement in acute lymphoblastic leukemia, and treatment of leptomeningeal malignancy. The authors outline the rationale, latest indications, surgical technique, and potential complications arising from the use of the Ommaya reservoir and other such subcutaneous reservoirs.
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