Nanovectorization of DNA Through Cells Using Protamine Complexation.

J Membr Biol

Nanomedicine, Imagery and Therapeutics Laboratory, EA - 4662, UFR Sciences et Techniques, CHU-UFR SMP, Université de Bourgogne Franche Comté, 19 Rue Ambroise Paré, 25030, Besancon Cedex, France.

Published: August 2016

Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.

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Source
http://dx.doi.org/10.1007/s00232-016-9890-5DOI Listing

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