AI Article Synopsis
- Chronic cluster headache is linked to abnormal tyrosine metabolism, showing high dopamine, tyramine, and noradrenaline levels, while octopamine and synephrine are lower in patients compared to controls.
- A study measured these amines in 23 chronic cluster headache sufferers and 16 controls to investigate these biochemical differences.
- The findings suggest that disruptions in tyrosine metabolism may contribute to the development of chronic cluster headache and are potential factors in the transition from episodic to chronic forms of the condition.
Article Abstract
Objective Episodic cluster headache is characterized by abnormalities in tyrosine metabolism (i.e. elevated levels of dopamine, tyramine, octopamine and synephrine and low levels of noradrenalin in plasma and platelets.) It is unknown, however, if such biochemical anomalies are present and/or constitute a predisposing factor in chronic cluster headache. To test this hypothesis, we measured the levels of dopamine and noradrenaline together with those of elusive amines, such as tyramine, octopamine and synephrine, in plasma of chronic cluster patients and control individuals. Methods Plasma levels of dopamine, noradrenaline and trace amines, including tyramine, octopamine and synephrine, were measured in a group of 23 chronic cluster headache patients (10 chronic cluster ab initio and 13 transformed from episodic cluster), and 16 control participants. Results The plasma levels of dopamine, noradrenaline and tyramine were several times higher in chronic cluster headache patients compared with controls. The levels of octopamine and synephrine were significantly lower in plasma of these patients with respect to control individuals. Conclusions These results suggest that anomalies in tyrosine metabolism play a role in the pathogenesis of chronic cluster headache and constitute a predisposing factor for the transformation of the episodic into a chronic form of this primary headache.
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| http://dx.doi.org/10.1177/0333102416640502 | DOI Listing |
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