Unit of Functional pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Published: September 2016
AI Article Synopsis
Article Abstract
Bis-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers, and human beings are exposed to DEHP via polyvinyl chloride (PVC) materials, medical equipment and even drinking water. While DEHP has been implicated to influence metabolism and endocrine functions, important questions remain about the molecular mechanisms of these effects. We employed the model organism Drosophila melanogaster and examined physiological, molecular and behavioural effects from DEHP-contaminated food. We found that DEHP, at levels comparable to human exposure, made male flies more resistant to starvation and increased lipid levels, while decreasing circulating carbohydrates. Moreover, DEHP-fed male flies had higher expression levels of an insulin-like peptide known to regulate metabolism, as well as the insulin receptor. Our results suggest that long-term DEHP feeding may induce diabetes-like dysfunctions. These findings provide a molecular background of how DEHP may have detrimental effects on metabolic functions.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia; Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, 3052, Australia.
Introduction: Phthalates, chemical additives used to enhance plastic products' flexibility, are easily released into the environment, and can harm the brain development through various mechanisms including inflammation. Genetic variation influencing an individual's susceptibility to inflammation may play a role in the effects of phthalate exposure on neurodevelopment however there is no summary measure developed for genetic susceptibility to inflammation.
Methods: We developed a genetic pathway function score for inflammation (gPFS), based on the transcriptional activity of the inflammatory response pathway in the brain and other tissues.
Phthalate acid esters (PAEs) and bisphenol A (BPA) are recognized as common endocrine disruptors associated with various adverse effects on human health. However, limitations in existing systematic studies, particularly in air detection, have raised concerns about potential health risks from inhalation exposure. In this study, PM samples were collected in Dongying, a petrochemical city, from October 27 to December 6, 2021.
The overall aim of the present study was to determine if exposure to three high volume plastic additives, including diethylhexyl phthalate (DEHP), bisphenol A (BPA) and benzotriazoles (BT), have the potential to promote adverse effects in Atlantic cod (G. morhua). Ex vivo precision cut - liver slices (PCLS) from six male juvenile Atlantic cod were exposed to four concentrations of mono-(2-ethylhexyl)-phthalate (MEHP, the main metabolite of DEHP), BPA and BT both singly and in mixtures ranging from 0.
More than 16,000 chemicals are incorporated into plastics to impart properties such as color, flexibility, and durability. These chemicals may leach from plastics, resulting in widespread human exposure during everyday use. Two plastic-associated chemicals-bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP)-and a class of chemicals-brominated flame retardants [polybrominated diphenyl ethers (PBDEs)]-are credibly linked to adverse health and cognitive impacts.
School of Environmental Science and Safety Engineering, Tianjin University of Technology, 391 Binshui West Rode, Xiqing District, Tianjin, 300384, China.
The chronic ecological risks posed by residual PAEs in China remain unclear. In this study, we analyzed the spatial distribution of five typical PAEs in the surface waters of China, dibutyl phthalate (DBP), diethylhexyl phthalate (DEHP), butylbenzyl phthalate (BBP), diethyl phthalate (DEP), and dimethyl phthalate (DMP). The highest concentration of PAEs were detected in the Liao River, ranging from 5 to 79.
