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Cannulae are tubular protein filaments that accumulate on the extracellular surface of the hyperthermophilic archaeon during cell division. Cannulae have been postulated to act as a primitive extracellular matrix through which cells could communicate or exchange material, although their native biological function remains obscure. Here, we report cryoEM structural analyses of cannulae and of protein assemblies derived from recombinant cannula-like proteins.
View Article and Find Full Text PDFA human skin-on-a-chip platform for microneedling-driven skin cancer treatment.
Mater Today Bio
February 2025
Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA, 90024, USA.
Skin-on-a-chip models provide physiologically relevant platforms for studying diseases and drug evaluation, replicating the native skin structures and functions more accurately than traditional 2D or simple 3D cultures. However, challenges remain in creating models suitable for microneedling applications and monitoring, as well as developing skin cancer models for analysis and targeted therapy. Here, we developed a human skin/skin cancer-on-a-chip platform within a microfluidic device using bioprinting/bioengineering techniques.
View Article and Find Full Text PDFStem cells adapt to their local mechanical environment by rearranging their cytoskeleton, which underpins the evolution of their shape and fate as well as the emergence of tissue structure and function. Here, in the second part of a two-part experimental series, we aimed to elucidate spatiotemporal cytoskeletal remodeling and resulting changes in morphology and mechanical properties of cells and their nuclei. Akin to mechanical testing of the most basic living and adapting unit of life, i.
View Article and Find Full Text PDFStem cell mechanoadaptation. I. Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling.
APL Bioeng
March 2025
Blue Mountains World Interdisciplinary Innovation Institute (bmwi3), Blue Mountains, New South Wales, Australia.
Here, we report on the first part of a two-part experimental series to elucidate spatiotemporal cytoskeletal remodeling, which underpins the evolution of stem cell shape and fate, and the emergence of tissue structure and function. In Part I of these studies, we first develop protocols to stabilize microtubules exogenously using paclitaxel (PAX) in a standardized model murine embryonic stem cell line (C3H/10T1/2) to maximize comparability with previously published studies. We then probe native and microtubule-stabilized stem cells' capacity to adapt to volume changing stresses effected by seeding at increasing cell densities, which emulates local compression and tissue template formation during development.
View Article and Find Full Text PDFBifunctional adsorbents based on hyper-cross-linked polymers containing carbonyl and amine species for the efficient removal of diclofenac from water in a broad pH range.
Environ Res
January 2025
Faculty of Chemistry, Adam Mickiewicz University, Poznań, ul. Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Development of new adsorbents for the efficient removal of organic pollutants from water is one of the most emerging environmental issues. Current studies in this field focus on improving the adsorption capacity of various materials and/or broadening the pH range in which the adsorbents can efficiently remove target pollutants. In this study, we designed bifunctional hyper-cross-linked polymers (HCPs) containing both carbonyl and amine species to investigate the effect of amine functional groups on the efficiency of adsorptive removal of non-steroidal anti-inflammatory drugs (NSAIDs) from water.
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