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Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
Sci Rep
January 2025
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to iron accumulation. This study aims to investigate the effects of Deferasirox on iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
View Article and Find Full Text PDFIron metabolism in a mouse model of hepatocellular carcinoma.
Sci Rep
January 2025
Institute of Comparative Molecular Endocrinology, Ulm University, 89081, Ulm, Germany.
Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinogenesis, we employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis and subsequent carcinogenesis.
View Article and Find Full Text PDFTranscriptomics study of hippocampus in mice exposed to heat stress.
Psychoneuroendocrinology
January 2025
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu, China. Electronic address:
Article Synopsis
- Heat stress (HS) prompts neuroinflammation and cognitive issues in the brain, leading to a study that compared the gene expression of mouse hippocampal tissue under HS conditions versus control.
- Analysis showed that HS exposure resulted in 210 differentially expressed genes, indicating significant changes, with 72 genes upregulated and 138 downregulated.
- Notably, the study found that taurine treatment could improve cognitive functions affected by HS, suggesting potential strategies for mitigating heat-induced cognitive impairments in vulnerable groups.
Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.
Hepatol Commun
January 2025
Liver Research Center, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health and National Clinical Research Center of Digestive Diseases, Beijing, China.
Article Synopsis
- Hepcidin, a hormone crucial for iron regulation, is shown to play a role in liver fibrosis by preventing hepatocyte apoptosis via the PERK pathway.
- A study using CCl4-induced liver fibrosis in hepcidin knockout mice revealed that the absence of hepcidin led to more severe liver damage and increased apoptosis compared to wild-type mice.
- Transcriptomic analysis identified that the PERK molecule is upregulated in the absence of hepcidin, suggesting its involvement in regulating cell death in liver injury, highlighting hepcidin's potential as a therapeutic target for liver fibrosis.
Identification of Ferroptosis-Related Gene in Age-Related Macular Degeneration Using Machine Learning.
Immun Inflamm Dis
December 2024
Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Background: Age-related macular degeneration (AMD) is a major cause of irreversible visual impairment, with dry AMD being the most prevalent form. Programmed cell death of retinal pigment epithelium (RPE) cells is a central mechanism in the pathogenesis of dry AMD. Ferroptosis, a recently identified form of programmed cell death, is characterized by iron accumulation-induced lipid peroxidation.
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