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CHIP: A new modulator of human malignant disorders. | LitMetric
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CHIP: A new modulator of human malignant disorders.

Zhe Cao Guanqiao Li Qianqian Shao Gang Yang Lianfang Zheng Taiping Zhang Yupei Zhao

Oncotarget

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Published: May 2016

Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin-proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045438PMC
http://dx.doi.org/10.18632/oncotarget.8219DOI Listing

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