AI Article Synopsis
- Osteosarcoma is the most common bone tumor in children and adolescents, and while surgery and multi-agent chemotherapy have improved survival rates, chemoresistance is a significant challenge.
- Research has focused on molecular targets and agents that influence cell death mechanisms such as apoptosis, autophagy, and necroptosis.
- The study summarizes how these new agents, including novel compounds, miRNAs, and proteins, interact with these pathways and their potential role in overcoming chemotherapy resistance in osteosarcoma.
Article Abstract
Osteosarcoma is the most common primary bone tumor in children and adolescents. Although combined therapy including surgery and multi-agent chemotherapy have resulted in great improvements in the overall survival of patients, chemoresistance remains an obstacle for the treatment of osteosarcoma. Molecular targets or effective agents that are actively involved in cell death including apoptosis, autophagy and necroptosis have been studied. We summarized how these agents (novel compounds, miRNAs, or proteins) regulate apoptotic, autophagic and necroptotic pathways; and discussed the current knowledge on the role of these new agents in chemotherapy resistance in osteosarcoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190133 | PMC |
| http://dx.doi.org/10.18632/oncotarget.8206 | DOI Listing |
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