Multiple Xanthogranulomas in an Adult: Known Entity, New Association.

J Cutan Med Surg

Division of Dermatology, Université de Montréal, Montreal, QC, Canada.

Published: September 2016

AI Article Synopsis

  • Multiple xanthogranulomas (XGs) in adults are rare, mostly associated with hematologic cancers, but many cases have unknown causes and can resolve on their own.
  • A case study details a 33-year-old woman with a gastrointestinal stromal tumor who developed eruptive XGs after one year of treatment with imatinib.
  • This case suggests a potential link between imatinib and the development of XG lesions and adds to the existing knowledge on adult XG associations.

Article Abstract

Background: Multiple xanthogranulomas (XGs) in adults are rare, although an increasing number of case reports are being published. The most frequent association is hematologic malignancies, but the majority of cases remain idiopathic, with occasional spontaneous resolution.

Objective: The aims of this report are to describe a case of eruptive XG in a woman with a solid neoplasia who was receiving imatinib and to review the literature.

Methods And Results: This 33-year-old woman had a gastrointestinal stromal tumor. After undergoing surgical removal and being on imatinib for 1 year, the patient developed multiple slightly erythematous papules with an orange hue on the axillary region, trunk, abdomen, and thighs. A biopsy confirmed the diagnosis of XG.

Conclusion: This is to the investigators' knowledge the first case of eruptive XG in the setting of a solid neoplasia. The possibility of drug-induced XG lesions due to imatinib cannot be excluded. This presentation could be added to the list of associations of adult XG.

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Source
http://dx.doi.org/10.1177/1203475416640795DOI Listing

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