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Curcumin enhances the anti-obesogenic activity of orlistat through SKN-1/NRF2-dependent regulation of nutrient metabolism in Caenorhabditis elegans.
Int J Obes (Lond)
January 2025
Laboratory of Metabolomics, Department of Biotechnology, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000, Plovdiv, Bulgaria.
Background: Metabolic dysregulation, a defining feature of obesity, disrupts essential signalling pathways involved in nutrient sensing and mitochondria homeostasis. The nuclear factor erythroid 2-related factor 2 (NRF-2) serves as a pivotal regulator of the cellular stress response, and recent studies have implicated it in the pathogenesis of obesity, diabetes, and metabolic syndrome. Curcumin, a polyphenolic compound derived from turmeric, has been identified as a potent activator of NRF-2.
View Article and Find Full Text PDFRotation symmetry mismatch and interlayer hybridization in MoS-black phosphorus van der Waals heterostructures.
Nat Commun
January 2025
School of Material Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, People's Republic of China.
Interlayer coupling in 2D heterostructures can result in a reduction of the rotation symmetry and the generation of quantum phenomena. Although these effects have been demonstrated in transition metal dichalcogenides (TMDs) with mismatched interfaces, the role of band hybridization remains unclear. In addition, the creation of flat bands at the valence band maximum (VBM) of TMDs is still an open challenge.
View Article and Find Full Text PDFEncapsulation of biomimetic nanozymes in MOF matrices as peroxidase mimetics for sensitive detection of L-cysteine.
Anal Methods
January 2025
Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering (SCME), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China.
Article Synopsis
- A new metal-organic framework (MOF)-encapsulated nanozyme was created to detect L-cysteine (L-Cys) using a simple color change method, enhancing both catalytic activity and stability.
- The system works by oxidizing a colorless reagent to a blue color, which then fades back to colorless upon L-Cys addition, allowing for easy visual detection and quantitative analysis.
- It shows excellent selectivity and resistance to interference with a low detection limit of 23.1 nm, indicating its strong potential for bioanalysis and early L-Cys diagnosis.
Key for Hexagonal Diamond Formation: Theoretical and Experimental Study.
J Am Chem Soc
January 2025
School of Materials, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
Hexagonal diamond (HD) was reported 60 years ago and has attracted extensive attention owing to its ultrahigh theoretical hardness, 58% superior to its cubic counterpart. However, to date, synthesizing pure HD under high-pressure and high-temperature (HPHT) remains unsuccessful due to the limitations of understanding the formation mechanism. In this work, employing a systematic molecular dynamics simulation, we directly observe the graphite-to-HD transition in a nucleation-growth mechanism.
View Article and Find Full Text PDFEarly Warning Signals of the Tipping Point in Strongly Interacting Rydberg Atoms.
Phys Rev Lett
December 2024
Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei, Anhui 230026, China.
The identification of tipping points is essential for the prediction of collapses or other sudden changes in complex systems. Applications include studies of ecology, thermodynamics, climatology, and epidemiology. However, detecting early signs of proximity to a tipping is made challenging by complexity and nonlinearity.
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