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Polycarbonate-Based Polymersome Photosensitizers with Cell-Penetrating Properties for Improved Killing of Cancer Cells.
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School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Polymer-based photosensitizers have found various applications in photodynamic therapy (PDT). However, the absence of targeting ability commonly results in a substantial reduction in photosensitizer accumulation at the tumor site, significantly limiting the therapeutic efficacy of the system. In addition, the development of biodegradable polymeric photosensitizers is of critical importance for biological applications.
View Article and Find Full Text PDFPolystyrene-Poly(acrylic acid) Block Copolymers for Encapsulation of Butyrylcholinesterase into Injectable Nanoreactors.
Biomolecules
December 2024
Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia.
The article is devoted to the creation of enzymatic nanoreactors based on polystyrene-block-poly(acrylic acid) (PS-b-PAA) copolymers containing bioscavengers capable of neutralizing toxic esters both in the body and in the environment. Block copolymers of different amphiphilicity, hydrophilicity and molecular weights were synthesized and characterized using gel permeation chromatography, NMR and UV spectroscopy. Polymeric nanocontainers in the absence and presence of human butyrylcholinesterase were made by film hydration and characterized by dynamic light scattering and microscopy methods.
View Article and Find Full Text PDFA Polypeptosome Spray To Heal Antibiotic-Resistant Bacteria-Infected Wound by Photocatalysis-Induced Metabolism-Interference.
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Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
With the booming antimicrobial drug resistance worldwide, traditional antibacterial agents (e.g., antibiotics) are usually powerless against superbug.
View Article and Find Full Text PDFBioresponsive Polymeric Nanoparticles: From Design, Targeted Therapy to Cancer Immunotherapy.
Biomacromolecules
January 2025
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, PR China.
Bioresponsive polymeric nanoparticles (NPs) that are capable of delivering and releasing therapeutics and biotherapeutics to target sites have attracted vivid interest in cancer therapy and immunotherapy. In contrast to enthusiastic evolution in the academic world, the clinical translation of these smart systems is scarce, partly due to concerns about safety, stability, complexity, and scalability. The moderate targetability, responsivity, and benefits are other concerns.
View Article and Find Full Text PDFThe effects of ligand distribution and density on the targeting properties of dual-targeting folate/biotin Pluronic F127/Poly (lactic acid) polymersomes.
Eur J Pharm Biopharm
January 2025
School of Life Science, Jiangxi Science and Technology Normal University, Jiangxi Key Laboratory of Natural Microbial Medicine Research, Key Laboratory of Microbial Resources and Metabolism of Nanchang City, Nanchang 330013, China. Electronic address:
Article Synopsis
- Dual-targeting polymersomes with biotin and folic acid were designed to improve targeting and anti-tumor effects in human ovarian cancer cells (OVCAR-3) compared to single-ligand systems.
- Two types of polymersomes were tested: one with both ligands in the same polymersome (BT/FA-F127-PLA) and one with ligands in separate polymersomes ((BT + FA)-F127-PLA), with the former showing better cell targeting and drug delivery results.
- The study found that effective cellular targeting is influenced by the ligands' ratio and the mechanisms of endocytosis, with optimal targeting achieved at a 7.5% biotin to 7.5%
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