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17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex.
Aging Cell
May 2021
Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
Article Synopsis
- Mice genetically heterogeneous from a specific cross showed a significant increase in male lifespan by 19% when fed a non-feminizing estrogen, 17-α-estradiol (17aE2), starting at 16 months and by 11% starting at 20 months.
- Other treatments tested, including nicotinamide riboside and three others, did not show substantial lifespan benefits for the mice.
- The study reinforces earlier findings about 17aE2, suggesting that it may offer important insights into sex-specific aging processes since it provided notable lifespan extensions even when dosing began later in life.
In vitro assessment of electrospun polyamide-6 scaffolds for esophageal tissue engineering.
J Biomed Mater Res B Appl Biomater
February 2019
Laboratory of Bioengineering and Regenerative Medicine (BioReM), Kazan Federal University, Kazan, Russia.
Artificial tissue-engineered grafts offer a potential alternative to autologous tissue grafts for patients, which can be traumatic. After decellularizing Papio hamadryas esophagus and studying the morphology and physical properties of the extracellular matrix (ECM), we generated electrospun polyamide-6 based scaffolds to mimic it. The scaffolds supported a greater mechanical load than the native ECM and demonstrated similar 3D microstructure, with randomly aligned fibers, 90% porosity, 29 μm maximal pore size, and average fiber diameter of 2.
View Article and Find Full Text PDFResponse to the 'Comments on "Cellular Therapies for Treatment of Radiation Injury after a Mass Casualty Incident" (Radiat Res 2017; 188:242-45)' by Drouet et al. (Letters to the Editor, Radiat Res 2017; 188:463).
Radiat Res
April 2018
d Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland.
Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop.
Radiat Res
August 2017
b Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
Article Synopsis
- Concerns about nuclear incidents are rising due to terrorist threats and potential natural or accidental disasters impacting nuclear reactors.
- Progress has been made globally in preparing for radiological events, but challenges remain in treating individuals affected by radiation injuries.
- Cellular therapies, including stem cells and mesenchymal stromal cells, show promise in aiding recovery for various organ systems affected by radiation exposure and were discussed at a 2015 international workshop.
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