In this work, a novel multifunctional NIR-sensitive nanoplatform has been developed for synergistic eradication of antibiotic-resistant bacteria based biofilms in vitro and in vivo. With high biocompatibility and an outstanding synergistic effect, our system provides a promising avenue to preventing and combating biofilm-associated infections.
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http://dx.doi.org/10.1039/c6cc00774k | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: () adheres to the surface of medical devices, forming highly drug-resistant biofilms, which has made the development of novel antibacterial agents against and its biofilms a key research focus. By drug repurposing, this study aims to explore the combinational antimicrobial effects between pinaverium bromide (PVB), a -type calcium channel blocker, and oxacillin (OXA) against .
Methods: Clinical isolates of were collected from January to September 2022 at the Department of Clinical Laboratory of the Third Xiangya Hospital, Central South University.
ACS Nano
March 2025
School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Wound-infected bacterial biofilms are protected by self-secreted extracellular polymer substances (EPS), which can confer them with formidable resistance to the host's immune responses and antibiotics, and thus delays in diagnosis and treatment can cause stubborn infections and life-threatening complications. However, tailoring an integrated theranostic platform with the capability to promptly diagnose and treat wound biofilm infection still remains a challenge. Herein, a versatile erbium-doped carbon dot-encapsulated zeolitic imidazolate framework-8 (Er:CDs@ZIF-8) nanoheterojunction (C@Z nano-HJ) is tailored and incorporated into gelatin methacrylate/poly(-hydroxyethyl acrylamide) (GelMA/PHEAA)-based tough and sticky hydrogel dressing (GH-C@Z) to achieve wound biofilm infection-integrated theranostic application.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
March 2025
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Nanotechnology Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutics Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Malignancies maintain a high rate of mortality worldwide each year, requiring the development of novel therapeutic platforms. Immunotherapy approaches are considered a revolutionary treatment for overcoming malignancies. Photodynamic therapy (PDT) has attracted significant attention in various cancer types.
View Article and Find Full Text PDFUltrason Sonochem
March 2025
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, Shandong University, Jinan, Shandong 250100, China. Electronic address:
Bacteria can encapsulate themselves in a self-generated matrix of hydrated extracellular polymeric substances such as polysaccharides, proteins, and nucleic acids, thereby forming bacterial biofilm infections. These biofilms are drug resistant and will diminish the efficacy of antimicrobial agents, rendering treatment of such infections challenging. Herein, an innovative strategy is proposed to synergistically degrade bacterial biofilms and eradicate the entrapped bacteria through integrating α-amylase (α-Amy), shikonin (SK) and epigallocatechin gallate (EGCG) within an emulsion.
View Article and Find Full Text PDFNano Lett
March 2025
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences, Beijing 100190, China.
Biofilms significantly impede the efficacy of conventional antimicrobial agents, particularly in multidrug-resistant (MDR) infections. In this work, we developed a size-adaptive, bismuth-based nanomicrobicide encapsulated with neutrophil membranes (BiS/SNP@CM), designed to selectively generate nitric oxide (NO) within acidic biofilms under near-infrared (NIR) irradiation. The nanomicrobicide's adaptive size ensures deeper biofilm penetration and accumulation, while the neutrophil membrane coating enhances biocompatibility and targeting at infection sites.
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