AI Article Synopsis
- A microfluidics method is used to create core-shell nanocarriers that can be adjusted for different pH levels.
- The outer shell safeguards the drug-containing core from being released in harsh pH environments like the gastrointestinal tract, but enables release near tumors.
- This innovative drug-delivery system is developed for delivering cancer treatments orally.
Article Abstract
A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
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| http://dx.doi.org/10.1002/adma.201502697 | DOI Listing |
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